This international break is the last one before domestic league action resumes until the end of the season.
England travel to Naples to play Italy at the Diego Armando Maradona Stadium in the first of two fixtures during the break, while the second qualifier sees England host Ukraine at Wembley.
When is the England squad announced?
The squad will be named on 16 March ahead of matchday 28 of the Premier League.
The international break begins on 20 March and will last until 29 March.
Who else could get an England call-up?
Starting in defence, with Harry Maguire losing his starting spot at club level, there is at least one spot potentially up for grabs. While Southgate has previously been happy to make an exception for the 30-year-old, this time there may be other defenders more deserving of a spot in the side.
Candidates to step up into his spot include Milan’s Fikayo Tomori, who missed out on the England squad travelling to Qatar for the World Cup.
Despite that decision, Southgate has kept in touch with the former Chelsea defender.
“Especially when I moved to Milan, he messaged me and spoke to me about it and when we used to go to the camps he would speak to me about how it was going,” said Tomori, after his side beat Tottenham in the Champions League in midweek.
“With him being a central defender, it was interesting to talk. He has always kept in contact and we will see what happens next week.”
According to The Athletic, Southgate is also an admirer of Levi Colwill and the Brighton defender could be a very viable choice at left centre-back, where depth is an issue for England. The Chelsea loanee is currently with Brighton’s U21 side after returning from a quadricep injury he picked up in training.
Brighton colleague Solly March is another player in contention for a call-up given his excellent form. Able to play on both the left and right flank, March’s versatility combined with his output of five goals and five assists so far has made him a vital cog in Roberto De Zerbi’s side.
“Obviously you want to represent your country, it’s a big honour. Now is probably the biggest chance I have to do that,” March recently told The Argus.
“It’s an ambition of mine so if I keep putting in performances and scoring goals I think I have a chance.”
In attacking midfield, Morgan Gibbs-White has been an exciting presence at Nottingham Forest since his summer move from Wolves, scoring twice and making five assists in the process. Southgate and assistant Steve Holland have been keeping track of his progress, with Holland even meeting the 23-year-old at Forest’s training ground.
With his ability to play across the forward line in various roles, Gibbs-White brings a lot to the table but faces strong competition from existing seniors in the squad including Bukayo Saka, Phil Foden and Jack Grealish.
Two strikers who have been making all the right noises this season are Aston Villa’s Ollie Watkins and Reims striker Folarin Balogun, who is on loan from Arsenal at the Ligue 1 outfit. Watkins has eight goals and four assists so far for Villa, with five of his goals coming in Villa’s last six matches.
As for Balogun, he has 15 goals for Reims, including four penalties, and has quickly emerged as one of the top strikers in French football.
It should be an excellent opportunity for Southgate to experiment.